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(73)K. Shindo, M. Endo, Y. Miyake, K. Wakasugi, D. Morritt, P. M. Bramley, P. D. Fraser, H. Kasai, and N. Misawa, Methyl Glucosyl-3,4-dehydro-apo-8’-lycopenoate, a Novel Antioxidative Glyco-C30-carotenoic Acid Produced by a Marine Bacterium Planococcus maritimus, J. Antibiotics, 61 (12), 729-735 (2008)

(73) K. Shindo, M. Endo, Y. Miyake, K. Wakasugi, D. Morritt, P. M. Bramley, P. D. Fraser, H. Kasai, and N. Misawa, Methyl Glucosyl-3,4-dehydro-apo-8’-lycopenoate, a Novel Antioxidative Glyco-C30-carotenoic Acid Produced by a Marine Bacterium Planococcus maritimus, J. Antibiotics, 61 (12), 729-735 (2008)

(72) M. A. Rahim, A. Nakajima, N. Misawa ,K. Shindo, K. Adachi, Y.
Shizuri, Y. Ohizumi, T. Yamakuni, A Novel Diol-derivative of Chalcone Produced by Bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, Activates PKA/MEK/ERK Signaling and Antagonizes Aβ-inhibition of the Cascade in Cultured rat CNS neurons, Molecular and Cellular Pharmacology, in press

(71) M. A. Rahim, A. Nakajima, N. Misawa ,K. Shindo, K. Adachi, Y. Shizuri, Y. Ohizumi, T. Yamakuni, A Novel Diol-derivative of Chalcone Produced by Bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, Activates Phosphorylation of ERK and CREB in Cultured Rat Cortical Neurons, Pharmacometrics, 74 (5/6), 131-135 (2008)

(70) T. Makino, H. Harada, H. Ikenaga, S. Matsuda, S. Takaichi, K. Shindo, G. Sandmann, T. Ogata, and N. Misawa, Characterization of Cyanobacterial b-Carotene Ketolase CrtW and Hydroxylase CrtR by Complementation Analysis in Escherichia coli, Plant and Cell Physiology, 49 (12), 1867-1878 (2008)

(69) T. Kawamura, E. Tashiro, K. Shindo and M. Imoto, SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 ActivationII. Structure Elucidation, J. Antibiot., 61 (5), 312-317 (2008)

(68) T. Kawamura, E. Tashiro, K. Yamamoto, K. Shindo and M. Imoto, SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation, I. Taxonomy, Fermentation, Isolation, Biological Activities and SAR Study, J. Antibiot., 61 (5), 303-311 (2008)

(67) T. Hasunuma, S. Miyazawa, S. Yoshimura, Y. Shinzaki, K. Tomizawa, K. Shindo, S. Choi, N. Misawa, C. Miyake,
Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering, The Plant Journal,  55 ( 5), 857-868 (2008
)

(66) O. Kagami, K. Shindo, A. Kyojima, K. Takeda, H. Ikenaga, K. Furukawa, and N. Misawa, Protein engineering on biphenyl dioxygenase for conferring activity to convert 7-hydroxyflavone and 5,7-dihydroxyflavone (chrysin), J. Biosci. and Bioeng., 106 (2), 121-127 (2008)

(65) K. Shindo, T. Hasunuma, E. Asagi, A. Sano, E. Hotta, N. Minemura, C. Miyake, T. Maoka, and N. Misawa, 4-Ketoantheraxanthin, a novel carotenoid produced by the combination of the bacterial enzyme b-carotene ketolase CrtW and endogenous carotenoid biosynthetic enzymes in higher plants, Tetrahedron Letters,  49 (20), 3294-3296 (2008)

(64) K. Shindo, E. Asagi, A. Sano, E. Hotta, N. Minemura, K. Mikami, E. Tamesada, N. Misawa, T. Maoka, Diapolycopenedioic acid xylosyl esters A, B, and C, novel antioxidative glyco-C30-carotenoic acids produced by a new marine bacterium Rubritalea squalenifaciens, J. Antibiot., 61 (3), 185-191 (2008)

(63) K. Shindo, E. Saito, M. Sekiya, T. Matsui, and Y. Koike, Antioxidative Activity of the Flower of Torenia fournieri, J. Nat. Med., 62 (2), 247-248 (2008)

(62) Y. Futamura, E. Tashiro, N. Hironiwa, J. Kohno, M. Nishio, K. Shindo and M. Imoto, Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.II. Structure Elucidation, J. Antibiot., 60 (9), 582-585 (2007)

(61) E. Ohkoshi, H. Miyazaki, K. Shindo, H. Watanabe, A. Yoshida, and H. Yajima, Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice, Planta Medica, 73, 1255-1259 (2007)

(60) K. Shindo, A. Osawa, Y. Kasai, N. Iba, A. Saotome, and N. Misawa, Hydroxylations of substituted naphthalenes by Escherichia coli expressing aromatic dihydroxylating dioxygenase genes from polycyclic aromatic hydrocarbon-utilizing marine bacteria, Journal of Molecular Catalysis B Enzymatic, 48 (3-4), 77-83 (2007)

(59) 新藤一敏、小池由貴子、丸山瑞、食用きのこヌメリスギタケモドキに含有される抗菌物質ビスノリアンゴニンの食品汚染微生物に対する作用、家政学会誌、58 (9), 563-568 (2007)

(58) H. Kasai, A. Katsuta, H. Sekiguchi, S. Matsuda, K. Adachi, K. Shindo, J. Yoon, and Y. Shizuri, Rubritalea squalenifaciens sp. nov. as a squalene-producing marine bacterium belonging to subdivison1 of Verrucomicrobia, Journal of Systematic and Evolutionary Microbiology, 57 (Pt 7), 1630-1634 (2007)

(57) K. Shindo, Y. Shindo, T. Hasegawa, A. Osawa, O. Kagami, K. Furukawa, and N. Misawa, Synthesis of Highly Hydroxylated Aromatics by Evolved Biphenyl Dioxygenase and Subsequent Dihydrodiol Dehydrogenase, Appl. Microbio. Biotech., 75 (5), 1063-1069 (2007)

(56) K. Shindo, K. Mikami, E. Tamesada, S. Takaichi, K. Adachi, N. Misawa, and T. Maoka, Diapolycopenedioic acid xylosyl ester, a novel glyco-C30-carotenoic acid produced by a new marine bacterium Rubritalea squalenifaciens, Tetrahedron Letters, 48 (15), 2725-2727 (2007)

(55) K. Shindo, K. Kikuta, A. Suzuki, A. Katsuta, H. Kasai, M. Yasumoto-Hirose, Y. Matuo, N. Misawa, and S. Takaichi, Rare carotenoids, (3R)-Saproxanthin and (3R,2’S)-myxol, isolated  from novel marine bacteria (Flavobacteriaceae) and their antioxidative activities, Appl. Microbio. Biotech., 74 (6), 1350-1357 (2007)

(54) K. Shindo, M. Kato, A. Kinoshita, A. Kobayashi and Y. Koike, Analysis of antioxidant activities contained in the Boesenbergia pandurata Schult. rhizome, Biosci. Biotechnol. Biochem, 70(9), 2281-2284 (2006)

(53) 新藤一敏、小池由貴子、丸山瑞、笠井宏朗、セロリアックに含有される抗菌化合物ファルカリンジオールのBacillus subtilisに対する作用、日本家政学会誌、57 (4), 209-214 (2006)

(52) Y. Takemoto, H. Watanabe, K. Uchida, K. Matsumura, K. Nakae, E. Tashiro, K. Shindo, T. Kitahara and M. Imoto, Chemistry and Biology of Moverastins, Inhibitors of Cancer Cell Migration, Produced by Aspergillus. Chemistry & Biology (Cambridge, MA, United States), 12(12), 1337-1347 (2005)

(51) T. Maruyama, M. Ishikura, H. Taki, K. Shindo, H. Kasai, M. Haga, Y. Inomata, and N. Misawa, Isolation and characterization of o-xylene oxygenase genes from Rhodococcus opacus TKN14, Appl. Environ. Microbiol., 71(12), 7705-7715 (2005)

(50) K. Shindo, R. Nakamura, A. Osawa, O. Kagami, K. Kanoh, K. Furukawa, and N. Misawa, Biocatalytic synthesis of monocyclic arene-dihydrodiols and -diols by Escherichia coli cells expressing hybrid toluene/biphenyl dioxygenase and dihydrodiol dehydrogenase genes, Journal of Molecular. Catalysis B: Enzymatic, 35, 134-141 (2005)


(49) X. Peng, K. Shindo, K. Kanoh, Y. Inomata, S. K. Choi, and N. Misawa, Characterization of Sphingomonas aldehyde dehydrogenase catalyzing the conversion of various aromatic aldehydes to their carboxylic acids. Appl. Microb. Biotechnol.. 69 (2), 141-150 (2005)

(48) Y. Nishida, K. Adachi, H. Kasai, Y. Shizuri, K. Shindo, A. Sawabe, S. Komemushi, W. Miki, and N. Misawa, Elucidation of a gene cluster encoding a novel carotenoid biosynthetic enzyme from Brevundimonas sp. SD212, 2,2’-beta-hydroxylase, and combinatorial biosynthesis of new or rare xanthophylls. Appl. Environ. Microbiol., 71 (8), 4286-4296 (2005)

(47) N. Misawa, R. Nakamura, Y. Kagiyama, H. Ikenaga, K. Furukawa, and K.Shindo, Synthesis of Vicinal Diols from Various Arenes with a Heterocyclic, Amino or Carboxyl Group by Using Recombinant Escherichia coli Cells Expressing Evolved Biphenyl Dioxygenase and Dihydrodiol Dehydrogenase Genes, Tetrahedron, 61, 195-204 (2005)

(46) K. Shindo, A. Osawa, R. Nakamura, Y. Kagiyama, S. Sakuda, Y. Shizuri, K. Furukawa, and N. Misawa, Conversion from Arenes Having a Benzene Ring to Those Having a Picolinic Acid by Simple Growing Cell Reactions Using Escherichia coli that Expressed the Six Bacterial Genes Involved in Biphenyl Catabolism, J. Am. Chem. Soc. 126 (46), 15042-15043 (2004)

(45) K. Shindo, M. Kimura, and M. Iga, Potent Antioxidative Activity of Cacalol, a Sesquiterpene Contained in Cacalia delphiniifolia Sleb et Zucc, Biosci. Biotechnol. Biochem., 68 (6), 1393-1394 (2004)

(44) A. Takami, M. Iwakubo, Y. Okada, T. Kawata, H. Odai, N. Takahashi, K. Shindo, K. Kimura, Y. Tagami, M. Miyake, K. Fukushima, M. Inagaki, M. Amano, K. Kaibuchi, and H. Iijima, Design and Synthesis of Rho Kinase Inhibitors (I), Bioorganic & Medicinal Chemistry, 12 (9), 2115-2137 (2004)

(43) 新藤一敏、増井直子、山田祐子、浅野雅子、中村良子、ひね生姜中の抗酸化成分の分離・同定およびその耐熱性について、日本家政学会誌、55 (5), 375-380 (2004)

(42) H. Chun, Y. Ohnishi, K. Shindo, N. Misawa, K. Furukawa and S. Horinouchi, Biotransformation of flavone and flavanone by Streptomyces lividans cells carrying shuffled biphenyl dioxygenase genes, Journal of Molecular Catalysis B: Enzymatic, 21, 113-121 (2003)

(41) Y. Kasai, K. Shindo, S. Harayama and N. Misawa, Molecular Characterization and Substrate Preference of a Polycyclic Aromatic Hydrocarbon Dioxygenase from Cycloclasticus sp. Strain A5, Appl Environ Microbiol. 69 (11), 6688-6697 (2003)

(40) S. Zenitani, K. Shindo, S. Tashiro, M. Sekiguchi, M. Nishimori, K. Suzuki and M. Imoto, Gerferlin, a Novel Inhibotor of Geranylgeranyl Diphosphate Synthase from Beauveria feline QN22047 II. Structural Elucidation, J. Antibiot., 56 (7), 658-660 (2003)

(39) S. Zenitani, S. Tashiro, K. Shindo, K. Nagai, K. Suzuki and M. Imoto. Gerfelin, a Novel Inhibitor of Geranylgeranyl Diphosphate Synthase from Beauveria feline QN22047. I. Taxonomy, Fermentation, Isolation and Biological Activities, J. Antibiot., 56 (7), 617-621 (2003)

(38) K. Shindo, Y. Kagiyama, R. Nakamura, A. Hara, H. Ikenaga, K. Furukawa, and N. Misawa. Enzymatic synthesis of novel antioxidant flavonoids by Escherichia coli cells expressing modified metabolic genes involved in biphenyl catabolism., Journal of Molecular Catalysis B, enzymatic. 23, 9-16 (2003)

(37) K. Shindo, R. Nakamura, I. Chinda, Y. Ohnishi, S. Horinouchi, H. Takahashi, K. Iguchi, S. Harayama, K. Furukawa and N. Misawa. Hydroxylation of ionized aromatics including carboxylic acid or amine using recombinant Streptomyces lividans cells expressing modified biphenyl dioxygenase genes. Tetrahedron. 59, 1895-1900 (2003)

(36) N. Misawa, K. Shindo, H. Takahashi, H. Suenaga, K. Iguchi, H. Okazaki, S. Harayama and K. Furukawa. Hydroxylation of various molecules including heterocyclic aromastics using recombinant Escherichia coli cells expressing modified biphenyl dioxygenase genes. Tetrahedron. 58, 9605-9612 (2002)

(35) K. Shindo, H. Suzuki and T. Okuda. Paecilopeptin, a new cathepsin S inhibitor produced by Paecilomyces carneus. Biosci. Biotechnol. Biochem. 66 (11), 2444-2448 (2002)

(34) Y. Murakami, M. Takei, K. Shindo, C. Kitazume, J. Tanaka, T. Higa and H. Fukamachi. Cyclotheonamode E4 and E5, New Potent Tryptase Inhibitors from an Ircinia Species of Sponge, Journal of Natural Products. 65 (3), 259-261 (2002)

(33) Y. Murakami, T. Okuda and K. Shindo. Roridin L, M and verrucarin M, new macrocyclic trichothecene group antitumor antibiotics, from Myrothecium verrucaria, J. Antibiotics. 54 (11), 980-983 (2001)

(32) K. Shindo, Y. Ohnishi, H. Chun, H. Takahashi, A. Saito, K. Iguchi, K. Furukawa, S. Harayama, S. Horinouchi and N. Misawa. Oxygenation reactions of various tricyclic fused aromatic compounds using Esherichia coli and Streptomyces lividans transformants carrying several arene dioxigenase genes. Biosci. Biotech. Biochem 65 (11), 2472-2481 (2001)

(31) H. Chun, Y. Ohnishi, N. Misawa, K. Shindo, M. Hayashi, S. Harayama and S. Horinouchi. Biotransformation of phenanthrene and 1-methoxynaphthalene with streptomyces lividans cells expressing a marinebacterialphenanthrene dioxygenase gene cluster. Biosci. Biotech. Biochem. 65 (8), 1774-1781 (2001)

(30) Y. Matsushima, T. Nakayama, M. Fujita, R. Bhandari, K. Shindo and K. Kakinuma. Isolation and structure elucidation of vicenistatin M, and importance of vicenisamine aminosugar for exerting cytotoxicity of vicenistatin. J. Antibiotics. 54 (3), 211-219 (2001)

(29) H.Suzuki, A. Ueno, M. Takei, K. Shindo, T. Higa and H. Hukamachi. The effects of S1319, a novel marine sponge-derived ?2-adrenoceptor agonist, on IgE-mediated activation of human cultured mast cells. Inflamn. Res., 49, 86-94 (2000)

(28) H. Suzuki, A. Ueno, M. Takei, K. Shindo, T. Miura, M. Sakakibara, T. Higa and H. Fukamachi. Tracheal relaxing effects and ?2 adrenoceptor selectivity of S1319, a novel sponge-derived bronchodilator agent, in isolated guinea-pig tissues. British Journal of Pharmacology, 128, 716-720 (1999)

(27) H. Suzuki, K. Shindo, A. Ueno, T. Miura, M. Takei, M. Sakakibara, H. Fukamachi, J. Tanaka and T. Higa. S1319: a novel ?-adrenoceptor agonist from marine sponge Dysidea sp. Bioorganic & Medicinal Chemistry Letters, 9, 1361-1364 (1999)

(26) Y. Tokoro, T. Isoe and K. Shindo. Gilvusmycin, a new antitumor antibiotic related to CC-1065. J. Antibiotics. 52 (3), 263-268 (1999)

(25) H. Arai, Y. Matsushima, T. Eguchi, K. Shindo and K. Kakinuma. Absolute stereochemistry of vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic. Tetrahedron Letters, 39, 3181-3184 (1998)

(24) M. Otsuka, T Eguchi, K. Shindo and K. Kakinuma. Non-fatty acyl polyketide starter in the biosynthesis of vicenistatin, an antitumor macrolactam antibiotic. Tetrahedron Letters, 39, 3185-3188 (1998).

(23) Y. Konishi and K. Shindo. Production of nigerose, nigerosyl glucose, and nigerosyl maltose by Acremonium sp. S4G13. Biosci. Biotech. Biochem., 61 (3), 439-442 (1997)

(22) M. Kato, Y. Miura, M. Kettoku, K.Shindo, A. Iwamatsu and K. Kobayashi. Reaction Mechanism of a new glycosyltrehalose-producing enzyme isolated from the hyperthermophillic archaeum, Sulfolobus solfataricus KM1. Biosci. Biotech. Biochem., 60 (5),921-924 (1996)

(21) M. Kato, Y. Miura, M. Kettoku, K. Shindo, A. Iwamatsu and K. Kobayashi. Purification and characterization of new trehalose-producing enzymes isolated from the hyperthermophilic archae, Sulfolobus solfataricus KM1. Biosci. Biotech. Biochem., 60 (3), 546-550 (1996)

(20) K. Shindo, M. Sakakibara, H. Kawai and H.Seto. Studies on cochleamycins, novel antitumor antibiotics III. biosyntheses of cochleamycins: incorporation of 13C- and 2H-labeled compounds into cochleamycins. J. Antibiotics, 49 (3), 249-252 (1996)

(19) K. Shindo, H. Iijima and H. Kawai. Studies on cochleamycins, novel antitumor antibiotics II. physico-chemical properties and structure determination. J. Antibiotics, 49 (3), 244-248 (1996)

(18) K. Shindo, M. Matsuoka and H. Kawai. Studies on cochleamycins, novel antitumor antibiotics I. taxonomy, production, isolation and biological activities. J. Antibiotics, 49 (3), 241-243 (1996)

(17) T. Sakai, K. Shindo, A Odagawa, A. Suzuki, H. Kawai, K. Kobayashi, Y. Hayakawa, H. Seto and N. Otake. Absolute configuration of spicamycin, an antitumor antibiotic produced by Streptomyces alanosinicus. J. Antibiotics, 48 (8),899-900 (1995)

(16) K. Shindo, Y. Yamagishi, Y. Okada and H. Kawai. Collismycins A and B, novel non-steroidal inhibitors of dexamethasone-glucocorticoide receptor binding. J. Antibiotics, 47 (9), 1072-1074 (1994)

(15) H. Odai, K. Shindo, A. Odagawa, J. Mochizuki, M. Hamada and T. Takeuchi. Inostamycin B and C, new polyether antibiotics. J. Antibiotics, 47 (8), 939-941 (1994)

(14) K. Shindo, Y. Yamagishi and H. Kawai. Thiazohalostatin, a new cytoprotective substance produced by Actinomadura . II physico-chemical properties and structure determination. J. Antibiotics, 46 (11), 1638-1642 (1993)

(13) Y. Yamagishi, M. Matsuoka, A. Odagawa, S. Kato, K. Shindo and J. Mochizuki. Thiazohalostatin, a new cytoprotective substance produced by Actinomadura. I taxonomy, production, isolation and biological activities. J. Antibiotics, 46 (11), 1633-1637 (1993)

(12) S. Kato, K. Shindo, Y. Yamagishi, M. Matsuoka, H. Kawai and J. Mochizuki. Phenazoviridin, a novel free radical scavenger from Streptomyces sp. . taxonomy, fermentation, isolation, structure elucidation and biological properties. J. Antibiotics, 46 (10), 1485-1493 (1993)

(11) K. Shindo, M. Kamishohara, A. Odagawa, M. Matsuoka and H. Kawai. Vicenistatin, a novel 20-membered macrocyclic antitumor antibiotic. J. Antibiotics, 46 (7), 1076-1081 (1993)

(10) O. Kikuchi, T. Eguchi, K. Kakinuma, Y. Koezuka, K. Shindo and N. Otake. Chemical transformation of gilvocarcin V modification of the side-chain. J. Antibiotics, 46 (6), 985-991 (1993)

(9) S. Kato, K. Shindo, H. Kawai, A. Odagawa, M. Matsuoka and J. Mochizuki. Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus taxonomy, fermentation, isolation, structure elucidation and biological properties. J. Antibiotics, 46 (6), 892-899 (1993)

(8) Y. Yamagishi, K. Shindo and H. Kawai. Rumbrin, a new cytoprotective substance produced by Auxarthron umbrinum II. physico-chemical properties and structure determination. J. Antibiotics, 46 (6), 888-891 (1993)

(7) Y. Yamagishi, M. Matsuoka, A. Odagawa, S. Kato, K. Shindo and J. Mochizuki. Rumbrin, a new cytoprotective substance produced by Auxarthon umbrinum I. taxonomy, production, isolation and biological activities. J. Antibiotics, 46 (6), 884-887 (1993)

(6) S. Kato, K. Shindo, H. Kawai, M. Matsuoka and J. Mochizuki. Studies on free radical scavenging substances from microorganisms III. isolation and structural elucidation of a novel free radical scavenger, resorstatin. J. Antibiotics, 46 (6), 1024-1026 (1993)

(5) K. Shindo and H. Kawai. A novel antibiotic, naphthopyranomycin. J. Antibiotics, 45 (4), 584-586 (1992)

(4) K. Shindo and H. Kawai. Novel antibiotics, Cochleamycin A and B. J. Antibiotics, 45 (2), 292-295 (1992)

(3) S. Kato, K. Shindo, Y. Kataoka, Y. Yamagishi and J. Mochizuki. Studies on radical scavenging substances from microorganisms II. neocarazostatins A, B and C, novel free radical scavengers. J. Antibiotics, 44 (8), 903-907 (1991)

(2) K. Shindo, A. Takenaka, T. Noguchi, Y. Hayakawa and H. Seto, Thiazostatin A and thiazostatin B, new antioxidants produced by Streptomyces tolurosus. J. Antibiotics, 42 (10), 1526-1529 (1989)

(1) A. Isogai, S. Sakuda, K. Shindo, S. Watanabe, A. Suzuki, S. Fujita and T. Furuya. Structure of cyclocarbamides A and B, new plant growth regulators from Streptoverticillium sp. Tetrahedron Letters, 27 (10), 1161-1164 (1986)



 
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(9) 新藤一敏、基礎分析学、日本女子大学教務・学生課、(2006).

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(5) 新藤一敏、健康を考えた食品学実験、アイ・ケイコーポレーション、25-28, 112-114 (2004)

(4) 新藤一敏、先端化学シリーズV 海洋天然物/錯体/コンビナトリアル/全合成、日本化学会、27-32 (2003)

(3) 新藤一敏、海洋天然物化学、社団法人日本化学会、33-38 (2002)

(2) 新藤一敏海綿から見つかった抗アレルギー薬、化学と生物、40, 13-14 (2002)

(1) 平井愛山、龍野一郎、三沢典彦、新藤一敏.薬用人参2000, 2.7.人参サポニン(ジンセノサイドRg3)ヒト血中濃度測定の試み、共立出版株式会社, 54-57 (2000)

 
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