PUBLICATIONS

研究成果

論文発表(主要論文を抜粋)

  • Afaf Eladl, Yudai Yamaoki, Keisuke Kamba, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Shou Waga, Takashi Nagata, and Masato Katahira.  NMR characterization of the structure of the intrinsically disordered region of human origin recognition subunit 1, hORC1, and ot its interaction with G-quadruplex DNAs.  Biochem. Biophys. Res. Commun. 683, 149112 (2023). Link to DOI
  • Aina Maria Mas, Enrique Goñi, Igor Ruiz de los Mozos, Aida Arcas, Luisa Statello, Jovanna González, Lorea Blázquez, Wei Ting Chelsea Lee, Dipika Gupta, Álvaro Sejas, Shoko Hoshina, Alexandros Armaos, Gian Gaetano Tartaglia, Shou Waga, Jernej Ule, Eli Rothenberg, María Gómez, and Maite Huarte.  ORC1 binds to cis-transcribed RNAs for efficient activation of replication origins.  Nat. Commun. 14, 4447 (2023).  Link to DOI
  • Afaf Eladl, Yudai Yamaoki, Shoko Hoshina, Haruka Horinouchi, Keiko Kondo, Shou Waga, Takashi Nagata, and Masato Katahira.  Investigation of the interaction of human origin recognition complex subunit 1 with G-quadruplex DNAs of human c-myc promoter and telomere regions.  Int. J. Mol. Sci. 22, 3481 (2021).  Link to DOI
  • Shoko Hoshina, Kei Yura, Honami Teranishi, Noriko Kiyasu, Ayumi Tominaga, Haruka Kadoma, Ayaka Nakatsuka, Tomoko Kunichika, Chikashi Obuse, and Shou Waga.  Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA.  J. Biol. Chem. 288, 30161-30171 (2013). Link to DOI
  • Christpher Van, Shan Yan, W.Matthew Michael, Shou Waga, and Karlene A. Cimprich.  Continued primer synthesis at stalled replication forks contributes to checkpoint activation.  J. Cell Biol. 189, 233-246 (2010). Link to DOI
  • Akiko Zembutsu and Shou Waga.  De novo assembly of genuine replication forks on an immobilized plasmid in Xenopus egg extracts.  Nucleic Acids Res. 34, e91 (2006). Link to DOI
  • Noriko Sasakawa, Tomoyuki Fukui and Shou Waga.  Accumulation of FFA-1, the Xenopus homolog of Werner helicase, and DNA polymerase delta on chromatin in response to replication fork arrest.  J. Biochem. 140, 95-103 (2006). Link to DOI
  • Shou Waga and Akiko Zembutsu.  Dynamics of DNA binding of replication initiation proteins de novo formation of pre-replicative complexes in Xenopus egg extracts.  J. Biol. Chem. 281, 10926-10934 (2006). Link to DOI
  • Tomoyuki Fukui, Kazumi Yamauchi, Taketo Muroya, Masahiro Akiyama, Hisaji Maki, Akio Sugino and Shou Waga.  Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extracts.  Genes to Cells 9, 179-191 (2004). Link to DOI
  • Asako Furukohri, Noriko Sato, Hisao Masai, Ken-ichi, Arai, Akio Sugino and Shou Waga.  Identification and characterization of Xenopus homolog of Dbf4, a regulatory subunit of Cdc7 protein kinase required for initiation of DNA replication.  J. Biochem. 134, 447-457 (2003). Link to DOI
  • Shou Waga, Taro Masuda, Haruhiko Takisawa, and Akio Sugino.  DNA polymerase epsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts.  Proc. Natl. Acad. Sci. USA 98, 4978-4983 (2001). Link to DOI
  • Shou Waga and Bruce Stillman.  The DNA replication fork in eukaryotic cells.  Annu. Rev. Biochem. 67, 721-51 (1998). Link to DOI
  • Tie-Hua Ni, William F. McDonald, Irene Zolotukhin, Thomas Melendy, Shou Waga, Bruce Stillman, and Nicholas Muzyczka.  Cellular protein required for adeno-associated virus DNA replication in the absence of adenovirus confection.  J. Virol. 72, 2777-2787 (1998). Link to DOI
  • Jens Oliver Funk, Shou Waga, Jo Beth Harry, Erik Espling, Bruce Stillman and Denise A. Galloway.  Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein.  Genes Dev. 11, 2090-2100 (1997). Link to DOI
  • Rong Li, Shou Waga, Gregory J. Hannon, David Beach and Bruce Stillman.  Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.  Nature, 371, 534-537 (1994).  Link to DOI
  • Shou Waga, Gregory J. Hannon, David Beach and Bruce Stillman.  The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA.  Nature, 369, 574-578 (1994). Link to DOI
  • Shou Waga and Bruce Stillman.  Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro.  Nature, 369, 207-212 (1994). Link to DOI
  • Shou Waga,Glenn Bauer and Bruce Stillman.  Reconstitution of complete SV40 DNA replication with purified replication factors.  J. Biol. Chem.269, 10923-10934 (1994). Link to DOI

学会発表(最近数年間の発表のみ抜粋)

  • 和賀祥、岩田麻由子、高野みなみ、西尾知紗、島田華奈.ヒトORCのグアニン四重鎖結合活性とORCA/LRWD1結合活性のクロマチン結合における役割.第47回日本分子生物学会年会(2024年12月27-29日、福岡)
  • Shou Waga, Minami Takano, Chisa Nishio, Kana Hosono, Yuna Akiniwa, Chiho Shioda. Pre-RC forming proteins commonly have G-quadruplex binding activity in the intrinsically disordered regions. The 12th 3R+3C International Symposium (2024年11月18-22日、福岡)
  • Shou Waga, Minami Takano, Chiho Shioda, Azusa Takahashi, Chisa Nishio, Runa Inagaki, Wakana Matsumoto, Yuna Akiniwa. Towards understanding for the biological significance of G-quadruplex DNA/RNA binding activity commonly seen in the human replication initiation proteins. 第97回日本生化学会大会(2024年11月6-8日、横浜)
  • 秋庭結奈、細野伽奈、和賀祥.ヒト複製開始因子Cdt1とCdc6のグアニン四重鎖結合.第46回日本分子生物学会年会(2023年11月27日ー12月1日、神戸)
  • 和賀祥、高野みなみ、島田華奈、能村さくら、岩田麻由子、秋庭結奈.ヒト複製開始因子に共通にみられるグアニン四重鎖結合活性の生物学的な意義の理解に向けて.第46回日本分子生物学会年会(2023年11月27日ー12月1日、神戸)
  • Shou Waga, Minami Takano, Kana Shimada, Mayuko Iwata, Yuna Akiniwa, Sakura Nomura, Chiho Shioda.  G-quadruplex binding may be the common characteristics of the intrinsically disordered regions of the proteins that function for pre-replicative complex formation in human cells. 第96回日本生化学会大会(2023年10月31日ー11月2日、福岡)
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